Recruiting: WA Summary: PGx-ADAPT is a multi-phase study working with GPs and practice teams to co-design a practical and equitable approach to pharmacogenetics-guided antidepressant prescribing in Western Australian primary care. The initial phase will explore practice staff knowledge, barriers and workflow needs, and gather feedback on a free GP-designed pharmacogenetics education...

Recruiting: VIC Summary: The ROSELLA study aims to evaluate the most effective method of delivering DNA-based cancer risk assessments in Australian general practice. We will examine whether DNA risk information helps people make decisions about their cancer screening, and other ways we can assist general practices to offer a DNA cancer...

Recruiting: VIC, QLD, SA Summary: EASSI-PC is a national clinical trials activity led by Bond University, the University of Melbourne, Adelaide University and the University of Newcastle, with recruitment coordinated by the Department of General Practice, Primary Care Trials Unit. We are inviting general practices to take part in a practical, real-world...

Recruiting TAS, SA, WA Summary: Scientists have discovered that a build-up of molecules in the blood may cause damage to brain capillaries, potentially contributing to Alzheimer’s disease. The primary objective of this trial is to evaluate the efficacy of Probucol (Lorelco) on cognitive performance in patients with Alzheimer’s disease (AD)...

Recruiting: National Summary: HF-REACH is a pioneering nationwide study testing whether nurse led management of heart failure patients is superior to usual care in a community health care setting. Using a smartphone-based mHealth platform monitored by specialist heart  failure nurses, who provide core intervention including remote haemodynamic monitoring (weight, blood pressure),...

Recruiting: WA Summary: People with type 2 diabetes are more likely to develop cardiovascular disease. The COLCOT-T2D trial aims to evaluate the efficacy and safety of colchicine and non enteric-coated aspirin, used either in combination or alone, to improve cardiovascular outcomes in high-risk patients with type 2 diabetes. GP requirements:...

Recruiting: National  Summary: The EASY-AS trial is investigating the most effective way to manage people with severe but asymptomatic aortic stenosis. It addresses a fundamental unresolved question in cardiology: the relative benefits of early aortic valve replacement (AVR) versus watchful waiting in asymptomatic patients with severe aortic stenosis. GP Requirements:...

Recruiting: National Summary: REST UP is evaluating an interactive digital CBTi program called Bedtime Window in aims to improve access to CBTi in rural and regional Australia. Practices will be allocated to either the self-guided digital CBTi, GP-guided digital CBTi, or augmented usual care (control) group, with control patients receiving access...

Recruiting: National Summary: Rotator cuff–related shoulder pain is common, affecting around 1.8 million Australians, with 40% experiencing disability beyond 12 months. This project aims to compare the effectiveness of internet-delivered care, with or without telehealth in addition to usual care, versus usual care alone on pain and disability, waiting times,...

Recruiting: QLD Summary: People with advanced cancer may experience a wide range of distressing and difficult-to-manage symptoms. MedCan 3 aims to reduce symptom burden in patients with advanced cancer by assessing the effect of escalating doses of THC/CBD 1:20 versus placebo on total symptom distress scores. GP Requirements: Referrers continue...